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Review ArticleR
Open Access

The Multiple Roles of Exosomes in Metastasis

ULRICH H. WEIDLE, FABIAN BIRZELE, GWEN KOLLMORGEN and RÜDIGER RÜGER
Cancer Genomics & Proteomics January 2017, 14 (1) 1-15;
ULRICH H. WEIDLE
1Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany
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FABIAN BIRZELE
2Roche Innovation Center Basel, F. Hoffman La-Roche, Basel, Switzerland
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GWEN KOLLMORGEN
1Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany
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RÜDIGER RÜGER
1Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany
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  • For correspondence: ruediger.rueger@roche.com
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Article Information

vol. 14 no. 1 1-15
PubMed 
28031234

Published By 
International Institute of Anticancer Research
Print ISSN 
1109-6535
Online ISSN 
1790-6245
History 
  • Received October 26, 2016
  • Revision received December 8, 2016
  • Accepted December 9, 2016
  • Published online December 28, 2016.

Copyright & Usage 
Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved

Author Information

  1. ULRICH H. WEIDLE1,
  2. FABIAN BIRZELE2,
  3. GWEN KOLLMORGEN1 and
  4. RÜDIGER RÜGER1⇑
  1. 1Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany
  2. 2Roche Innovation Center Basel, F. Hoffman La-Roche, Basel, Switzerland
  1. Correspondence to: Rüdiger Rüger, Roche Innovation Center Munich, Roche Diagnostics GmbH, Im Nonnenwald 2, D-82372 Penzberg, Germany. Tel: +49 8856602022, e-mail: ruediger.rueger{at}roche.com
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Cancer Genomics - Proteomics: 14 (1)
Cancer Genomics & Proteomics
Vol. 14, Issue 1
January-February 2017
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The Multiple Roles of Exosomes in Metastasis
ULRICH H. WEIDLE, FABIAN BIRZELE, GWEN KOLLMORGEN, RÜDIGER RÜGER
Cancer Genomics & Proteomics Jan 2017, 14 (1) 1-15;

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The Multiple Roles of Exosomes in Metastasis
ULRICH H. WEIDLE, FABIAN BIRZELE, GWEN KOLLMORGEN, RÜDIGER RÜGER
Cancer Genomics & Proteomics Jan 2017, 14 (1) 1-15;
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  • Article
    • Abstract
    • General Features of Exosomes
    • Exosomes – Functions in Cancer
    • Exosomes Derived from Cancer Cells as Mediators of Migration and Invasion
    • Concept of Pre- and Metastatic Niche
    • Pre-metastatic Niche of Melanoma in Lymph Nodes
    • CD44v6-promoted Metastatic Niche Formation in a Rat Pancreatic Tumor Model
    • Metastatic Niche of Melanoma in the Lung
    • Metastatic Niche of Pancreatic Carcinoma in the Liver
    • Exosome Mediated Interplay Between Tumor Cells with Fibroblasts, Astrocytes and Adipocytes Resulting in Metastasis
    • Metastasis-related Interactions Between Cancer Cell-derived Exosomes and Endothelial Cells
    • Metastasis Promotion by Exosomes Based on Immuno-suppression
    • Exosome-mediated Organotropism of Metastasis
    • Translational Aspects
    • Footnotes
    • References
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Keywords

  • Exosome interaction with stromal cells
  • organ tropism of metastasis
  • pre- and metastatic niche
  • review
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