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Research Article
Open Access

Does Post-Surgery Placement of Rectus Sheath Block Analgesia Alter the Oxidative Stress Biomarker 8-OHdG Concentrations: A Randomised Trial of Patients with Cancer and Benign Disease

MARTIN PURDY, MERJA KOKKI, MAARIT ANTTILA, SAMULI ASPINEN, PETRI JUVONEN, TUOMAS SELANDER, HANNU KOKKI, KARI PULKKI and MATTI ESKELINEN
Cancer Genomics & Proteomics May 2016, 13 (3) 239-244;
MARTIN PURDY
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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MERJA KOKKI
2Department of Anaesthesia and Operative Services, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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MAARIT ANTTILA
3Department of Gynaecology, Kuopio University Hospital, Kuopio, Finland
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SAMULI ASPINEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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PETRI JUVONEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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TUOMAS SELANDER
4Science Service Center, Kuopio University Hospital, Kuopio, Finland
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HANNU KOKKI
2Department of Anaesthesia and Operative Services, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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KARI PULKKI
5Department of Clinical Chemistry, School of Medicine, University of Eastern Finland, Kuopio, Finland
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MATTI ESKELINEN
1Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland
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  • For correspondence: matti.eskelinen{at}kuh.fi
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    Figure 1.

    Flowchart of the study design.

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    Figure 2.

    The jitter plots of the individual hs-CRP (C-reactive protein) values versus 8-OHdG (8-hydroxy-2’-deoxyguanosine) values post-surgery (POP1) for the placebo group and three study groups (r=-0.4, p=0.02).

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    Figure 3.

    The jitter plots of the individual postoperative NRS (11-point numeric rating scale) values versus 8-OHdG (8-hydroxy-2’-deoxyguanosine) values post-surgery (POP1) for the placebo group and three study groups (r=-0.01, p=ns).

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Cancer Genomics & Proteomics
Vol. 13, Issue 3
May-June 2016
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Does Post-Surgery Placement of Rectus Sheath Block Analgesia Alter the Oxidative Stress Biomarker 8-OHdG Concentrations: A Randomised Trial of Patients with Cancer and Benign Disease
MARTIN PURDY, MERJA KOKKI, MAARIT ANTTILA, SAMULI ASPINEN, PETRI JUVONEN, TUOMAS SELANDER, HANNU KOKKI, KARI PULKKI, MATTI ESKELINEN
Cancer Genomics & Proteomics May 2016, 13 (3) 239-244;

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Does Post-Surgery Placement of Rectus Sheath Block Analgesia Alter the Oxidative Stress Biomarker 8-OHdG Concentrations: A Randomised Trial of Patients with Cancer and Benign Disease
MARTIN PURDY, MERJA KOKKI, MAARIT ANTTILA, SAMULI ASPINEN, PETRI JUVONEN, TUOMAS SELANDER, HANNU KOKKI, KARI PULKKI, MATTI ESKELINEN
Cancer Genomics & Proteomics May 2016, 13 (3) 239-244;
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  • Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer
  • Brief Pain Inventory (BPI) Pain Survey Versus Cysteine Protease Caspase-1 (Casp1) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer
  • Plasma Concentration of the Lipid Peroxidation (LP) Biomarker 4-Hydroxynonenal (4-HNE) in Benign and Cancer Patients
  • The Induction of Antioxidant Catalase Enzyme With Decrease of Plasma Malonidialdehyde: An Important Reactive Oxidative Species Inhibiting Mechanism
  • The Rectus Sheath Block (RSB) Analgesia Following Laparotomy Could Affect Malonidialdehyde (MDA) Concentrations in Benign Disease and Cancer
  • Brief Pain Inventory (BPI) Health Survey After Midline Laparotomy With the Rectus Sheath Block (RSB) Analgesia: A Randomised Trial of Patients With Cancer and Benign Disease
  • Rectus Sheath Block (RSB) Analgesia Could Enhance Significantly the Patient Satisfaction Following Midline Laparotomy in Benign Disease and in Cancer: A Prospective Study With Special Reference to Nitrosative Stress Marker Nitrotyrosine (NT) Plasma Concentrations
  • Plasma Catalase in Relation to Pain Following Midline Laparotomy: A Prospective Study of Patients with Benign Diseases and Patients with Cancer
  • Gallstone Patients with Enhanced Oxidative Stress Biomarker Superoxide Dismutase (SOD1) Plasma Levels Have Significantly Lower Number of Postoperative Analgesic Oxycodone Doses: A Prospective Study with Special Reference to Cancer Patients
  • Patients with Increased Levels of the Oxidative Stress Biomarker SOD1 Appear to Have Diminished Postoperative Pain After Midline Laparotomy: A Randomised Trial with Special Reference to Postoperative Pain Score (NRS)
  • Characterization of Prognostic Factors and the Efficacy of Adjuvant S-1 Chemotherapy in Patients with Post-surgery Extrahepatic Bile Duct Cancer
  • Plasma Glutathione Peroxidase (GPX1) Levels and Oxidative Stress in Gallstone Patients Operated with Two Different Cholecystectomy Techniques: A Randomized Study with Special Reference to Cancer Patients
  • Does Rectus Sheath Block Analgesia Alter Levels of the Oxidative Stress Biomarker Glutathione Peroxidase: A Randomised Trial of Patients with Cancer and Benign Disease
  • Does the Rectus Sheath Block Analgesia Reduce the Inflammatory Response Biomarkers' IL-1ra, IL-6, IL-8, IL-10 and IL-1{beta} Concentrations Following Surgery? A Randomized Clinical Trial of Patients with Cancer and Benign Disease
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Keywords

  • cancer
  • oxidative stress
  • 8-OHdG
  • analgesia
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