Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance

Altered expression of transient receptor potential (TRP) channels in human cancer. A: Heat map representing the median values of expression of TRP channel genes (ratio of cancer to normal). N: Not available. B: Network visualizing the association between TRP channel isotypes (gray nodes) and cancer types (pale red nodes). Line colors represent up (red)- or down (blue)-regulation of TRP channel genes and line width indicates their expression levels in cancer. CCC, Clear cell carcinoma; PCC, papillary cell carcinoma; AC, adenocarcinoma; SCC, squamous cell carcinoma; TRPC, transient receptor potential channels canonical; TRPV, transient receptor potential channels vanilloid; TRPM, transient receptor potential channels melastatin; TRPML, transient receptor potential channels mucolipin; TRPP, transient receptor potential channels polycystin; TRPA, transient receptor potential channels ankyrin.