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Review ArticleR

Genomics and Proteomics Approaches for Biomarker Discovery in Sporadic Colorectal Cancer with Metastasis

MARÍA GONZÁLEZ-GONZÁLEZ, JACINTO GARCIA GARCIA, JOSÉ ANTONIO ALCAZAR MONTERO, LUIS MIGUEL GONZÁLEZ FERNANDEZ, OSCAR BENGOECHEA, OSCAR BLANCO MUÑEZ, ALBERTO ORFAO, J.M. SAYAGUES and MANUEL FUENTES
Cancer Genomics & Proteomics January 2013, 10 (1) 19-25;
MARÍA GONZÁLEZ-GONZÁLEZ
1 Servicio General de Citometría, Departamento de Medicina and Centro de Investigación del Cáncer
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JACINTO GARCIA GARCIA
2 Unit of Cirugía, Hospital Universitario de Salamanca-IIBSAL, Salamanca, Spain
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JOSÉ ANTONIO ALCAZAR MONTERO
2 Unit of Cirugía, Hospital Universitario de Salamanca-IIBSAL, Salamanca, Spain
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LUIS MIGUEL GONZÁLEZ FERNANDEZ
2 Unit of Cirugía, Hospital Universitario de Salamanca-IIBSAL, Salamanca, Spain
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OSCAR BENGOECHEA
3 Unit of Unidad de Patología, Hospital Universitario de Salamanca-IIBSAL, Salamanca, Spain
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OSCAR BLANCO MUÑEZ
3 Unit of Unidad de Patología, Hospital Universitario de Salamanca-IIBSAL, Salamanca, Spain
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ALBERTO ORFAO
1 Servicio General de Citometría, Departamento de Medicina and Centro de Investigación del Cáncer
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J.M. SAYAGUES
1 Servicio General de Citometría, Departamento de Medicina and Centro de Investigación del Cáncer
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MANUEL FUENTES
1 Servicio General de Citometría, Departamento de Medicina and Centro de Investigación del Cáncer
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Abstract

Sporadic colorectal cancer (sCRC) is one of the most frequent types of cancer in Europe. Despite understanding of its tumorigenesis, the metastatic process is not yet clear. In this article, we review the most significant genetic and proteomic advances that have been made in regards to research of the sCRC metastatic process, and the new biomarkers that are able to predict disease prognosis or response to treatments, in order to define personalized medicine.

  • Sporadic colorectal carcinoma
  • metastases
  • genomic biomarkers
  • proteomic biomarkers
  • review
  • Received May 20, 2012.
  • Revision received October 23, 2012.
  • Accepted October 29, 2012.
  • Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinasios), All rights reserved
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Cancer Genomics - Proteomics: 10 (1)
Cancer Genomics & Proteomics
Vol. 10, Issue 1
January-February 2013
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Genomics and Proteomics Approaches for Biomarker Discovery in Sporadic Colorectal Cancer with Metastasis
MARÍA GONZÁLEZ-GONZÁLEZ, JACINTO GARCIA GARCIA, JOSÉ ANTONIO ALCAZAR MONTERO, LUIS MIGUEL GONZÁLEZ FERNANDEZ, OSCAR BENGOECHEA, OSCAR BLANCO MUÑEZ, ALBERTO ORFAO, J.M. SAYAGUES, MANUEL FUENTES
Cancer Genomics & Proteomics Jan 2013, 10 (1) 19-25;

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Genomics and Proteomics Approaches for Biomarker Discovery in Sporadic Colorectal Cancer with Metastasis
MARÍA GONZÁLEZ-GONZÁLEZ, JACINTO GARCIA GARCIA, JOSÉ ANTONIO ALCAZAR MONTERO, LUIS MIGUEL GONZÁLEZ FERNANDEZ, OSCAR BENGOECHEA, OSCAR BLANCO MUÑEZ, ALBERTO ORFAO, J.M. SAYAGUES, MANUEL FUENTES
Cancer Genomics & Proteomics Jan 2013, 10 (1) 19-25;
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  • Article
    • Abstract
    • Genomic Alterations Involved in Liver Metastatic sCRC
    • Proteomic Alterations Involved in Liver Metastatic sCRC
    • Identification of Biomarkers in Metastatic sCRC
    • Discovery of Biomarkers from Genomic Approaches
    • Discovery of Biomarkers by Proteomic Approaches
    • Future of Biomarkers for Metastatic sCRC
    • Conflicts of Interest
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Keywords

  • Sporadic colorectal carcinoma
  • metastases
  • genomic biomarkers
  • proteomic biomarkers
  • review
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