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History
- Received December 21, 2012
- Revision received January 23, 2013
- Accepted January 23, 2013
- Published online February 4, 2013.
Copyright & Usage
Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinasios), All rights reserved
Author Information
- 1 Roche Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
- 2 Department of Biology II, Ludwig Maximilian University, Munich, Germany
- Correspondence to: Ulrich H. Weidle, Roche Pharma Research and Early Development (pRED), Roche Diagnostics GmbH, Nonnenwald 2, D-82372 Penzberg, Germany. E-mail: ulrich.weidle{at}roche.com
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- Article
- Abstract
- Formats
- Initial Efforts to Recruit Immune Effector Cells Using Bispecific Antibodies
- Targeting CD28 for Recruitment of Immune Effector Cells
- Trifunctional Bispecific Antibodies
- Bipecific T-Cell Engagers (BiTEs)
- Further Formats for Recruitment of Immune Effector Cells
- Single-chain Triple Antibodies
- Cytotoxic Bispecific Antibodies
- Bispecific Antibodies Directed against Receptor-tyrosine Kinases
- Bispecific Antibodies Interfering with Tumor Angiogenesis
- Bispecific Antibodies for Targeting of Intracellular Antigens
- Conclusion
- References
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