Abstract
Virally-associated cancers are unique in that their origin is typically well defined and suitable to genomic analysis on a smaller scale. We recently reported the transcription profile of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in Kaposi's sarcoma (KS) using a real-time quantitative PCR (QPCR) array. This review explores the advantages and limitations of such an approach as well as the possibilities of extending PCR-based profiling to human cancers. Since real-time QPCR records a truly quantitative transcription profile, this technology will improve statistical analysis and solidify clinical decision-making.
Footnotes
- Received November 5, 2003.
- Accepted February 28, 2004.
- Copyright© 2004 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved