High-throughput genomic technologies continuously advance and offer new opportunities to better understand and treat cancer. The past decade has seen a plethora of next-generation sequencing and data analysis studies, allowing us to map the genomic landscapes of various cancer types, while single cell analyses are shedding light on tumor heterogeneity. Groundbreaking new technologies, such as spatial omics, can give us unprecedented insight into the spatiotemporal tumor architecture and micro-environment. In this regard, this special issue aims to bring together review articles, experimental and clinical studies on the following topics:

- Whole-genome sequencing

- Single-cell genomics

- Mutational signatures

- Spatial transcriptomics

- Epigenomics

- Multi-omics

- Tumor architecture

- Tumor progression

- Data analysis methods / bioinformatics /machine learning

- Tumor heterogeneity

- Circulating tumor cells

- Precision medicine

- Tumor microenvironment interactions

- Computational immunology

- New therapeutic targets

 Publication date: December 1, 2023; Submission deadline: November 3, 2023.

 Instructions for the preparation and submission of reviews and original articles.